In-vitro Antioxidant Activity and Cytotoxic Effect of Ethanol Leaf Extract and Fractions of Olax subscorpioidea Oliv. (Olacaceae)

The Olax subscorpioidea (Oliv) plant belongs to the Olacaceae family. It is a local remedy used in Nigeria treat wide range of conditions, including cancer. This study examined fractions and ethanol leaf extract for phytochemical content, antioxidant activity, cytotoxic activity. Using accepted methods, total tannin (TTC), flavonoid (TFC), phenolic (TPC) were assessed. activities determined through DPPH, ABTS, OH methods. lethality assay brine shrimp was determine ethyl acetate fraction (OSEA) had highest yields (148.7 ± 2.41 mg GAE), (145.5 9.49 mg/QUE), (35.8 2.15 GAE) capacity (94.7 1.47 as well lowest IC50 values DPPH (0.315 0.004 mg/ml), ABTS (0.329 0.0195 hydroxyl (5.910 0.0244 mg/ml). high concentration compounds suggests its scavenging potential compared with other fractions. All at LC50 less than 200 µg/ml. However, hexane more value 39.254 activity associated presence secondary such compounds, tannin, present plant.